Knowledge Center

Patent / Jan 01, 1999

Process for the preparation of purified crystalline iohexol by crystallization using ethanol

Authors:
  • Guy Villax
  • Alexandre Carvalho
Source:
EP 919540

Hydrophobic contaminants (e.g., O-alkylated derivs.) and residual org. solvents are removed from the X-ray contrast agent iohexol by the use of a solvent such as ethanol which the iohexol is insol. one procedure, ethanol is added to aq. soln. of iohexol. another procedure, the iohexol is suspended ethanol and then allowed to crystallize. Cryst. iohexol having a residual solvent content

Also in the Knowledge Center

Related Content

PowdAir, a simple capsule based inhaler

PowdAir is a simple, easy to use, capsule based dry powder inhaler with excellent performance.

Page
Read more

Regulatory Affairs

Hovione has filings with every world health authority that has a DMF system for APIs including FDA EDQM PMDA,MHRA, HPRA, Infarmed among others.

Page
Read more

Devices

Hovione offers simple, patented and globally competitive dry powder inhalers – Disposable, Capsule, Blister and Large Dose DPIs – which are available for fully integrated turn-key development with formulation and for licensing.

Page
Read more