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Patent / Jan 01, 1973

Corticosteroid 21-sulfates and 21-phosphates

Authors:

Ivan Villax

Source:

GB 1395820

Diidopregnadienedione I (R = R1 = I) (II) was treated with Me2CO contg. K2HPO4 and H3PO4 or MeCN-Me2CO contg. Et3N.H3PO4 to give betamethasone phosphate (I; R = H, R1 = OPO3H2), which yielded 1:1 and 2:1 salts with PhCH2NHCH2CH2NHCH2Ph. Treatment of II with K2SO4 and H2SO4 yielded betamethasone sulfate (I, R = H, R1 = OSO3H).

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Knowledge Center

Corticosteroid 21-sulfates and 21-phosphates

Also in the Knowledge Center

Design, preparation and characterization of novel molecularly imprinted polymers for removal of potentially genotoxic 1,3-diisopropylurea from API solutions

Design of experiments as a tool for LC-MS/MS method development for the trace analysis of the potentially genotoxic 4-dimethylaminopyridine impurity in glucocorticoids

Carcinogenic pollutants in drug manufacturing

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