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Patent / Jan 01, 1973

Corticosteroid 21-sulfates and 21-phosphates

Authors:

Ivan Villax

Source:

GB 1395820

Diidopregnadienedione I (R = R1 = I) (II) was treated with Me2CO contg. K2HPO4 and H3PO4 or MeCN-Me2CO contg. Et3N.H3PO4 to give betamethasone phosphate (I; R = H, R1 = OPO3H2), which yielded 1:1 and 2:1 salts with PhCH2NHCH2CH2NHCH2Ph. Treatment of II with K2SO4 and H2SO4 yielded betamethasone sulfate (I, R = H, R1 = OSO3H).

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Knowledge Center

Corticosteroid 21-sulfates and 21-phosphates

Also in the Knowledge Center

Process for the preparation of purified crystalline iohexol by crystallization using ethanol

Process for the preparation of crystalline and solvent-free iohexol

Isolation and x-ray crystal structure analysis of a hydrazine-containing rhodium catalyst, [(MeOH)2H]+[RhCl4(PPh3)(NHMeNHMe)]-

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