Knowledge Center

Patent / Jan 01, 1973

Catalytic dehalogenation, alone or with simultaneous reduction, of 11a-halo-6-deoxy-6-demethyl, 6-methylenetetracyclines by hydrazine

Authors:
  • Ivan Villax
Source:
GB 1360006

Methacycline and .alpha.- and .beta.-doxycycline sulfosalicylates were prepd. by dehalogenating 11a-chloro-6-deoxy-6-demethyl-6-methylene-5-hydroxytetracycline hydrofluoride or p-toluenesulfonate with N2H4.H2O-Pd-C and treating with 5-sulfosalicylic acid.

Also in the Knowledge Center

Related Content

Technologies

We offer a number of innovative particle engineering technologies, at all scales, to address recent challenges in drug delivery.

Page
Read more

Wet Polishing

This is a proprietary Hovione technology for addressing complex particle reduction challenges.

Page
Read more

Sunriser® DPI

High Performance, High-Dose Capsule DPI.

Page
Read more