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Patent / Jan 01, 1973

Catalytic dehalogenation, alone or with simultaneous reduction, of 11a-halo-6-deoxy-6-demethyl, 6-methylenetetracyclines by hydrazine

Authors:

Ivan Villax

Source:

GB 1360006

Methacycline and .alpha.- and .beta.-doxycycline sulfosalicylates were prepd. by dehalogenating 11a-chloro-6-deoxy-6-demethyl-6-methylene-5-hydroxytetracycline hydrofluoride or p-toluenesulfonate with N2H4.H2O-Pd-C and treating with 5-sulfosalicylic acid.

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Knowledge Center

Catalytic dehalogenation, alone or with simultaneous reduction, of 11a-halo-6-deoxy-6-demethyl, 6-methylenetetracyclines by hydrazine

Also in the Knowledge Center

Use of PAT tools in the development, monitor and control of continuous manufacturing processes

Enhancing the “right first time” concept in Continuous Manufacturing – Development strategy

A novel amorphous solid dispersion based on drug-polymer complexation

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