Knowledge Center

Patent / Jan 01, 1973

16.beta.-Methyl-17.alpha.-hydroxypregna-1,4,9(11)-triene-3,20-dione and analogs

Authors:
  • Ivan Villax
Source:
GB 1397267

Pregnatrienedione I was prepd. from epoxypregnanetrione II in 7 steps. Thus, II underwent ketalization with HOCH2CH2OH, KBH4 redn., dehydration, Grignard reaction with MeMgBr, and deketalization to give pregnenedione III. III was treated with Br2-HOAc and then debrominated to I.

Also in the Knowledge Center

Related Content

Formulation

We develop inhalation & nasal products with our partners following Quality by Design principles to reach optimal product performance through robust processes.

Page
Read more

Hovione awarded prestigious industry medal by Macau Government

Press Release / Dec 22, 2023
Article
View

Areas of Expertise

Hovione analytical chemists master several areas of knowledge

Page
Read more