Knowledge Center

Patent / Jan 01, 1973

16.beta.-Methyl-17.alpha.-hydroxypregna-1,4,9(11)-triene-3,20-dione and analogs

Authors:
  • Ivan Villax
Source:
GB 1397267

Pregnatrienedione I was prepd. from epoxypregnanetrione II in 7 steps. Thus, II underwent ketalization with HOCH2CH2OH, KBH4 redn., dehydration, Grignard reaction with MeMgBr, and deketalization to give pregnenedione III. III was treated with Br2-HOAc and then debrominated to I.

Also in the Knowledge Center

Related Content

Sunriser® DPI

High Performance, High-Dose Capsule DPI.

Page
Read more

Continuous Tableting for Drug Product

Hovione´s pragmatic approach to bridging science with manufacturing is now being leveraged for continuous tableting and it is the key to ultimately providing high quality medicines and the success of your drug product.

Page
Read more

Areas of Expertise

Hovione analytical chemists master several areas of knowledge

Page
Read more