Knowledge Center

Patent / Jan 01, 1973

16.beta.-Methyl-17.alpha.-hydroxypregna-1,4,9(11)-triene-3,20-dione and analogs

Authors:
  • Ivan Villax
Source:
GB 1397267

Pregnatrienedione I was prepd. from epoxypregnanetrione II in 7 steps. Thus, II underwent ketalization with HOCH2CH2OH, KBH4 redn., dehydration, Grignard reaction with MeMgBr, and deketalization to give pregnenedione III. III was treated with Br2-HOAc and then debrominated to I.

Also in the Knowledge Center

Related Content

What we do

Hovione is a Contract Development and Manufacturing Company dedicated to helping Pharmaceutical Customers bring new and off-patent drugs to market.

Page
Read more

Analytical Characterization

Hovione advanced characterization capabilities of inhalation and nasal products is crucial to determine their safety and efficacy.

Page
Read more

Customers

Full transparency for your project anywhere at any time.

Page
Read more