Knowledge Center

Patent / Jan 01, 1976

Sulfate and phosphate 21-esters of corticosteroids

Authors:
  • Ivan Villax
Source:
US 3773803

Betametasone (I) 21-phosphate (II) was prepd. in 96.7% yield by refluxing III (R = I) in 40 ml acetone with 1.2 g H3PO4 and 5.8 ml Et3N for 3.5 hr. Salts of I 21-sulfate and II with PhCH2NHCH2CH2NHCH2Ph also were prepd.

Also in the Knowledge Center

Related Content

Particle Engineering for Inhalation and Nasal

Hovione is a global expert and recognized leader in particle engineering, an essential technology when developing inhalation drug products.

Page
Read more

Hovione and GEA Strengthen Partnership to Advance Continuous Tableting Technology

Press Release / Mar 18, 2024
Article
View

Management

Hovione is an independent family owned international group of companies.

Page
Read more