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Patent / Jan 01, 1976

Sulfate and phosphate 21-esters of corticosteroids

Authors:

Ivan Villax

Source:

US 3773803

Betametasone (I) 21-phosphate (II) was prepd. in 96.7% yield by refluxing III (R = I) in 40 ml acetone with 1.2 g H3PO4 and 5.8 ml Et3N for 3.5 hr. Salts of I 21-sulfate and II with PhCH2NHCH2CH2NHCH2Ph also were prepd.

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Knowledge Center

Sulfate and phosphate 21-esters of corticosteroids

Also in the Knowledge Center

Electrophilic reagents for monohalomethylation, their preparation and their uses

Continuous production of particles, micro- and/or nanoparticles, particulate amorphous solid dispersions, particulate co-crystals and pharmaceutical compns.

Dry-Powder Inhalation Formulation: Balancing Performance and Manufacturability

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