Knowledge Center

Patent / Jan 01, 1976

Sulfate and phosphate 21-esters of corticosteroids

Authors:
  • Ivan Villax
Source:
US 3773803

Betametasone (I) 21-phosphate (II) was prepd. in 96.7% yield by refluxing III (R = I) in 40 ml acetone with 1.2 g H3PO4 and 5.8 ml Et3N for 3.5 hr. Salts of I 21-sulfate and II with PhCH2NHCH2CH2NHCH2Ph also were prepd.

Also in the Knowledge Center

Related Content

Continuous Flow

Expand the established chemistry space with Continuous Flow to deliver robust and sustainable processes.

Page
Read more

Areas of Expertise

Hovione analytical chemists master several areas of knowledge

Page
Read more

Analytical Characterization

Hovione advanced characterization capabilities of inhalation and nasal products is crucial to determine their safety and efficacy.

Page
Read more