Knowledge Center

Patent / Jan 01, 1976

Sulfate and phosphate 21-esters of corticosteroids

Authors:
  • Ivan Villax
Source:
US 3773803

Betametasone (I) 21-phosphate (II) was prepd. in 96.7% yield by refluxing III (R = I) in 40 ml acetone with 1.2 g H3PO4 and 5.8 ml Et3N for 3.5 hr. Salts of I 21-sulfate and II with PhCH2NHCH2CH2NHCH2Ph also were prepd.

Also in the Knowledge Center

Related Content

Filling

Fully-integrated Filling for your device needs.

Page
Read more

Drug delivery platforms

Hovione has unique capabilities and expertise in solubility enhancement, lung delivery, modified release and taste-masking applications.

Page
Read more

Health, Safety, Environment and Energy (HSEEn)

Zero accidents is our main goal

Page
Read more