Knowledge Center

Patent / Jan 01, 1984

Rhodium-containing catalysts and their application

Authors:
  • Philip Page
Source:
EP 86046

A catalyst for hydrogenating tetracycline intermediates was prepd. by treating a Rh phosphine complex with a hydrazine. Thus (Ph3P)3RhCl was treated with N2H4 to give a catalyst contg. 16.95% Rh which was used together with PPh3 to hydrogenate I (RR1 = CH2) to give I (R = Me, R1 = H) free from epimer.

Also in the Knowledge Center

Related Content

Drug Substance Capabilities

Focused expertise in Drug Substance manufacturing processes.

Page
Read more

Large Dose DPI

Disposable DPI for high dose drug delivery.

Page
Read more

Spray drying

Spray drying has become one of the most successful particle engineering technologies for improving drug bioavailability through the amorphous solid dispersion platform.

Page
Read more