Knowledge Center

Patent / Jan 01, 2006

Process for preparation of fluticasone analogs via esterification of a carbothioic acid

Authors:
  • Luis Sobral
  • William Heggie
Source:
WO 2006043015

A process for prepg. esters, such as I (R = CO(CH2)n, COCHMe2, n = 1, 2), was disclosed and comprised esterification of the C-17 hydroxyl group of 6?,9?-difluoro-11?,17?-dihydroxy-16?-methyl-3-oxoandrosta-1,4-diene-17?-carbothioic acid I (R = H) with a slight excess of a corresponding acyl chloride, RCOCl, inert solvent the presence of a tertiary amine.

Also in the Knowledge Center

Related Content

Macau 10th November

Gallery of photos - the best moments of the event

Page
Read more

Continuous Tableting for Drug Product

Hovione´s pragmatic approach to bridging science with manufacturing is now being leveraged for continuous tableting and it is the key to ultimately providing high quality medicines and the success of your drug product.

Page
Read more

Covid-19 / Coronavirus

Stay updated with the latest information on Covid-19

Page
Read more