Knowledge Center

Patent / Jan 01, 2006

Process for preparation of fluticasone analogs via esterification of a carbothioic acid

Authors:
  • Luis Sobral
  • William Heggie
Source:
WO 2006043015

A process for prepg. esters, such as I (R = CO(CH2)n, COCHMe2, n = 1, 2), was disclosed and comprised esterification of the C-17 hydroxyl group of 6?,9?-difluoro-11?,17?-dihydroxy-16?-methyl-3-oxoandrosta-1,4-diene-17?-carbothioic acid I (R = H) with a slight excess of a corresponding acyl chloride, RCOCl, inert solvent the presence of a tertiary amine.

Also in the Knowledge Center

Related Content

Virtual Tours

Our doors are open. Welcome to our facilities. We are a Contract Development and Manufacturing Company dedicated to helping Pharmaceutical Customers bring new and off-patent drugs to market.

Page
Read more

ASD-HIPROS

ASD-HIPROS, Hovione’s Intelligent Proprietary Screening, is the most advanced and accurate tool to identify Amorphous Solid Dispersion formulations by Spray Drying with maximum performance and stability.

Page
Read more

Sustainability

Hovione is committed to doing its part for a better world.

Page
Read more