Knowledge Center

Patent / Jan 01, 2006

Process for preparation of fluticasone analogs via esterification of a carbothioic acid

Authors:
  • Luis Sobral
  • William Heggie
Source:
WO 2006043015

A process for prepg. esters, such as I (R = CO(CH2)n, COCHMe2, n = 1, 2), was disclosed and comprised esterification of the C-17 hydroxyl group of 6?,9?-difluoro-11?,17?-dihydroxy-16?-methyl-3-oxoandrosta-1,4-diene-17?-carbothioic acid I (R = H) with a slight excess of a corresponding acyl chloride, RCOCl, inert solvent the presence of a tertiary amine.

Also in the Knowledge Center

Related Content

Spray congealing

Spray congealing, also known as spray cooling, is a solvent free process that transforms a melt into well defined spherical particles.

Page
Read more

Jet milling

Jet milling is widely used in the pharmaceutical industry and remains the leading technology for particle size reduction and is most commonly used for having consistent and uniform particles during formulation.

Page
Read more

Our Experts

Exceptional people ensure exceptional projects.

Page
Read more