Knowledge Center

Patent / Jan 01, 2007

Process for the manufacture of iohexol by the alkylation of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide with 1-chloro-2,3-propanediol using 2-(2-methoxyethoxy)ethanol as the reaction solvent

Authors:
  • Jose Galindro
  • Joao Bandarra
  • William Heggie
Source:
WO 2007060380

A process for the prodn. of iohexol comprises alkylating 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide with 1-chloro-2,3-propanediol using 2-(2-methoxyethoxy)ethanol as the reaction solvent the presence of a base (e.g., sodium hydroxide).

Also in the Knowledge Center

Related Content

Formulation

We develop inhalation & nasal products with our partners following Quality by Design principles to reach optimal product performance through robust processes.

Page
Read more

Wet Polishing

This is a proprietary Hovione technology for addressing complex particle reduction challenges.

Page
Read more

Sustainability

Hovione is committed to doing its part for a better world.

Page
Read more