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Patent / Jan 01, 1977

Polyphosphate complexes of 6-demethyl-6-deoxy-6-methylenetetracycline and its 11a-halo derivatives

Authors:

Ivan Villax

Source:

ES 420504

5-Hydroxytetracycline 6,12-hemiacetal 12-phosphite was dehydrated by P2O5 to give 6-deoxy-6-demethyl-6-methylene-5-hydroxytetracycline polymetaphosphate. Similarly prepd. was 11a-chloro-6-deoxy-6-demethyl-6-methylene-5-hydroxytetracycline metaphosphate.

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Knowledge Center

Polyphosphate complexes of 6-demethyl-6-deoxy-6-methylenetetracycline and its 11a-halo derivatives

Also in the Knowledge Center

Scale-up methodology for pharmaceutical spray drying

Mixing simulation tools in process development

Screening methodologies to expedite the formulation development of amorphous solid dispersions

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