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Patent / Jan 01, 1977

Polyphosphate complexes of 6-demethyl-6-deoxy-6-methylenetetracycline and its 11a-halo derivatives

Authors:

Ivan Villax

Source:

ES 420504

5-Hydroxytetracycline 6,12-hemiacetal 12-phosphite was dehydrated by P2O5 to give 6-deoxy-6-demethyl-6-methylene-5-hydroxytetracycline polymetaphosphate. Similarly prepd. was 11a-chloro-6-deoxy-6-demethyl-6-methylene-5-hydroxytetracycline metaphosphate.

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Knowledge Center

Polyphosphate complexes of 6-demethyl-6-deoxy-6-methylenetetracycline and its 11a-halo derivatives

Also in the Knowledge Center

Electrophilic reagents for monohalomethylation, their preparation and their uses

Continuous production of particles, micro- and/or nanoparticles, particulate amorphous solid dispersions, particulate co-crystals and pharmaceutical compns.

Dry-Powder Inhalation Formulation: Balancing Performance and Manufacturability

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