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Patent / Jan 01, 2011

Methods and compounds for the preparation of monofluoromethylated biologically active organic compounds

Authors:

Emilia Leitao

Source:

WO 2011151625

Processes were disclosed for the prepn. of monofluoromethylated org. biol. active compds., such as fluticasone propionate and fluticasone furoate I [R = CH2Me, 2-furanyl, resp.], in the presence of fluorodecarboxylating reagents such as XeF2 and BrF3

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Knowledge Center

Methods and compounds for the preparation of monofluoromethylated biologically active organic compounds

Also in the Knowledge Center

Electrophilic reagents for monohalomethylation, their preparation and their uses

Continuous production of particles, micro- and/or nanoparticles, particulate amorphous solid dispersions, particulate co-crystals and pharmaceutical compns.

Dry-Powder Inhalation Formulation: Balancing Performance and Manufacturability

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