Knowledge Center

Patent / Jan 01, 2002

Crystallization process for the preparation of crystalline and solvent-free iohexol

Authors:
  • Guy Villax
  • Carlos Alvarez
Source:
US 6469208

Industrial process for the purifn. and removal of residual solvents from iohexol, is presented which is based on the suspension of cryst. iohexol, eventually contg. residual solvents above 100 ppm, a fluid whereit has a low soly., followed by heating, filtration, and drying. This process enables the formation of cryst. iohexol with no residual org. residual solvent above 100 ppm and with increased purity level.

Also in the Knowledge Center

Related Content

Regulatory Affairs

Hovione has filings with every world health authority that has a DMF system for APIs including FDA EDQM PMDA,MHRA, HPRA, Infarmed among others.

Page
Read more

Procurement

We partner, connect and align to shape supplier solutions that help Hovione reach its growth and objectives.

Page
Read more

Inspections History

Hovione sites are periodically inspected by the local and external authorities. All sites are FDA approved and with exception of New Jersey site all have EU GMP certificates.

Page
Read more