Knowledge Center

Patent / Jan 01, 1973

Corticosteroid 21-sulfates and 21-phosphates

Authors:
  • Ivan Villax
Source:
GB 1395820

Diidopregnadienedione I (R = R1 = I) (II) was treated with Me2CO contg. K2HPO4 and H3PO4 or MeCN-Me2CO contg. Et3N.H3PO4 to give betamethasone phosphate (I; R = H, R1 = OPO3H2), which yielded 1:1 and 2:1 salts with PhCH2NHCH2CH2NHCH2Ph. Treatment of II with K2SO4 and H2SO4 yielded betamethasone sulfate (I, R = H, R1 = OSO3H).

Also in the Knowledge Center

Related Content

Macau 10th November

Gallery of photos - the best moments of the event

Page
Read more

Drug delivery platforms

Hovione has unique capabilities and expertise in solubility enhancement, lung delivery, modified release and taste-masking applications.

Page
Read more

OWN it! Training and Development Needs FY24

Take an active role in your personal development. Follow the new process to identify, plan and own your training and development needs for FY24.

Page
Read more