Knowledge Center

Patent / Jan 01, 1973

Corticosteroid 21-sulfates and 21-phosphates

Authors:
  • Ivan Villax
Source:
GB 1395820

Diidopregnadienedione I (R = R1 = I) (II) was treated with Me2CO contg. K2HPO4 and H3PO4 or MeCN-Me2CO contg. Et3N.H3PO4 to give betamethasone phosphate (I; R = H, R1 = OPO3H2), which yielded 1:1 and 2:1 salts with PhCH2NHCH2CH2NHCH2Ph. Treatment of II with K2SO4 and H2SO4 yielded betamethasone sulfate (I, R = H, R1 = OSO3H).

Also in the Knowledge Center

Related Content

The Hovione Experience - Lisbon

Welcome to Lisbon! Part of The Hovione Experience is ensuring your trip is unforgettable. Explore our suggestions for iconic attractions, exquisite cuisine, and get ready to feel the magic of this vibrant city.

Page
Read more

The Hovione Experience - Cork

Welcome to Cork! Explore the city’s hidden gems and breathtaking scenery with us! Indulge in the Hovione Experience and immerse yourself in Irish culture.

Page
Read more

Inhalation devices

Hovione’s inhalers offer our business partners access to simple, multipurpose, easy to use, globally competitive alternatives for inhalation delivery devices.

Page
Read more