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Patent / Jan 01, 1973

Catalytic dehalogenation, alone or with simultaneous reduction, of 11a-halo-6-deoxy-6-demethyl, 6-methylenetetracyclines by hydrazine

Authors:

Ivan Villax

Source:

GB 1360006

Methacycline and .alpha.- and .beta.-doxycycline sulfosalicylates were prepd. by dehalogenating 11a-chloro-6-deoxy-6-demethyl-6-methylene-5-hydroxytetracycline hydrofluoride or p-toluenesulfonate with N2H4.H2O-Pd-C and treating with 5-sulfosalicylic acid.

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Knowledge Center

Catalytic dehalogenation, alone or with simultaneous reduction, of 11a-halo-6-deoxy-6-demethyl, 6-methylenetetracyclines by hydrazine

Also in the Knowledge Center

A method of preparing amorphous solid dispersion in submicron range by co-precipitation

Green production of cocrystals using a new solvent-free approach by spray congealing

Production of nano-solid dispersions using a novel co-precipitation process – benchmarking the in vivo performance with spray dried dispersions

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