Knowledge Center

Patent / Jan 01, 1972

9-Fluoro-16.beta.-methyl steroids

Authors:
  • Ivan Villax
Source:
US 3792046

The title compds. (I) were prepd. from pregnatriene (II) by treatment with MeCONHBr and aq. HClO4 to give the 9.alpha.-bromo-11.beta.-hydroxy deriv., treatment with NaOH to give the 9,11-epoxy deriv. which was treated with aq. HF to give I (R = H) which could be treated with I-MeOH in the presence of CaO to give the 21-diiodo deriv. which was treated with KOAc, giving I (R = OAc).

Also in the Knowledge Center

Related Content

Epidel™

Epidel™ is an innovative technology with the ability to deliver sustained-release pharmaceuticals via surface erosion resulting in the ability to precisely tune pharmacokinetics to meet the target indication needs.

Page
Read more

Wet Polishing

This is a proprietary Hovione technology for addressing complex particle reduction challenges.

Page
Read more

Hovione at a glance

Get to know more about our history

Page
Read more