Knowledge Center

Patent / Jan 01, 1973

16.beta.-Methyl-17.alpha.-hydroxypregna-1,4,9(11)-triene-3,20-dione and analogs

Authors:
  • Ivan Villax
Source:
GB 1397267

Pregnatrienedione I was prepd. from epoxypregnanetrione II in 7 steps. Thus, II underwent ketalization with HOCH2CH2OH, KBH4 redn., dehydration, Grignard reaction with MeMgBr, and deketalization to give pregnenedione III. III was treated with Br2-HOAc and then debrominated to I.

Also in the Knowledge Center

Related Content

Formulation

We develop inhalation & nasal products with our partners following Quality by Design principles to reach optimal product performance through robust processes.

Page
Read more

Chromatography

Hovione has expanded its purification technologies to include chromatography to support development from lab to commercial scale.

Page
Read more

Sustainability

Hovione is committed to doing its part for a better world.

Page
Read more