Knowledge Center
Patent / Jan 01, 1973
16.beta.-Methyl-17.alpha.-hydroxypregna-1,4,9(11)-triene-3,20-dione and analogs
Source:
GB 1397267
Pregnatrienedione I was prepd. from epoxypregnanetrione II in 7 steps. Thus, II underwent ketalization with HOCH2CH2OH, KBH4 redn., dehydration, Grignard reaction with MeMgBr, and deketalization to give pregnenedione III. III was treated with Br2-HOAc and then debrominated to I.
Also in the Knowledge Center
/ Mar 02, 2021
Investigating crystallization tendency, miscibility, and molecular interactions of drug-polymer systems for the development of amorphous solid dispersions
Read more
Scientific Article
/ Jul 08, 2021
Augmenting Adaptive Machine Learning with Kinetic Modeling for Reaction Optimization
Read more
Scientific Article
Scientific Article