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Patent / Jan 01, 1973

16.beta.-Methyl-17.alpha.-hydroxypregna-1,4,9(11)-triene-3,20-dione and analogs

Authors:

Ivan Villax

Source:

GB 1397267

Pregnatrienedione I was prepd. from epoxypregnanetrione II in 7 steps. Thus, II underwent ketalization with HOCH2CH2OH, KBH4 redn., dehydration, Grignard reaction with MeMgBr, and deketalization to give pregnenedione III. III was treated with Br2-HOAc and then debrominated to I.

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Knowledge Center

16.beta.-Methyl-17.alpha.-hydroxypregna-1,4,9(11)-triene-3,20-dione and analogs

Also in the Knowledge Center

Rhodium-containing hydrogenation catalysts for the conversion of methacycline to doxycycline

Rhodium hydrogenation catalysts particularly for stereoselective hydrogenation of methacycline to doxycycline

Homogeneous catalytic system for hydrogenation of methylenetetracyclines and a process for the preparation of same

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