Knowledge Center

Patent / Jan 01, 1973

16.beta.-Methyl-17.alpha.-hydroxypregna-1,4,9(11)-triene-3,20-dione

Authors:
Source:
GB 1397267

16.alpha.,-17-Epoxypregnane-3,11,20-trione was ketalized with HOCH2CH2- OH and then reduced by KBH4 to give the bis(ethylenedioxy) pregnanediol I, which reacted with MeMgBr to give pregnenedione II, after hydrolysis. The 2,4-dibromo deriv. of II was debrominated in DMF contg. Li2- CO3 and LiBr to give the title compd. III.

Also in the Knowledge Center

Related Content

Customers

Full transparency for your project anywhere at any time.

Page
Read more

Hot melt extrusion

Hot melt extrusion is a fast growing technology platform thas is utilized to solve difficult formulation challenges, primarily in the area of solubilization.

Page
Read more

Technologies

We offer a number of innovative particle engineering technologies, at all scales, to address recent challenges in drug delivery.

Page
Read more