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Press Clipping / Feb 18, 2018

Invest in talent to find future leaders

The Sunday Times, February 18, 2018

Smart companies are focusing on internal training schemes to develop and mentor graduate employees.

The challenge of attracting the right people in a highly competitive recruitment market is leading many organisations to consider developing their own talent from within. While formal graduate programmes are nothing new in larger organisations, such schemes are becoming more common at smaller companies.

Recruitment firm Fastnet, which has offices in Cork and Dublin, has been successful at developing its own talent rather than hiring from competitors over the past 15 or 20 years, according to managing partner Niamh O’Driscoll. She said a formal graduate programme that brings people into the company at a very early stage was the next logical step.

The first two graduates- one with a psychology degree and the other with a biochemistry background- have been taken on for the two year rotational programme. After six months getting to grips with all aspects of Fastnet’s business, the new hires will work in the talent acquisition division, focused initially on quality and laboratory, and then on engineering.

“We have a very specific methodology and core values”, said O’ Driscoll. “The programme allows us to instil our values from the beginning and will help ensure there is a consistent pipeline of quality talent coming up”.

Portuguese pharmaceutical company Hovione, which has a contract manufacturing site in Cork that employs more than 200 people, has also been looking at innovative ways of developing talent.

“We’re quite a small company so we’re not going to have a huge internal mentoring or graduate recruitment programme” said human resources director Mary Hennessy. “We’ve tried to align with international programmes where we can facilitate one or two graduates.”

INOV Contacto, is an EU-funded scheme that enables young Portuguese’s workers to work abroad for six months as interns in multinational companies. In Hovione’s case, the candidates typically have a master’s degree or a PHD in chemistry.

“At the end of the placement it’s up to us if we want to offer a full-time position” said Hennessy. “Both of the participants so far have stayed with us and relocated to Cork as process engineers”.

The company also participates in the Ibec Global Graduates Programme, taking on two people through this route each year. The 12 month programme involves six months working with the Cork team and six months based in one of the other Hovione sites in Lisbon, New Jersey or Macau. The company has gone on to hire six graduates through this programme.

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Continuous Tableting (CT) is defined as continuous manufacturing of oral dose drugs, specifically tablets. As per ICH's Q13 definition1, a continuous manufacturing process in the pharmaceutical industry comprises at least two unit operations integrated from a mechanical and software perspective. There is a wide combination of possible CT process configurations that are dependent on the needs of the intended product formulation and each of the individual unit operations that constitute the process train can be continuous, semi-continuous, or batch processes. The typical manufacturing processes for tablet formulation are direct compression (DC), dry granulation (DG) and wet granulation (WG)2 - details on these manufacturing processes are beyond the scope of this article, so the interested reader is directed to relevant literature. The actual implementation of CT technology in a facility can broadly vary depending on the level of desired integration and automation. Process trains can be designed to be flexible and converted between multiple configurations (e.g. continuous DC, DG and WG), controlled by the end user from one single software and within a single clean room. The other possibility would be for subsections of the CT process to be divided into multiple clean rooms where inprocess materials are transferred between suites via a bin-to-bin approach (e.g. a granulation suite to prepare granules from raw materials followed by continuous DC (CDC) to blend the granules and produce tablets). The level of automation and instrumentation designed into the CT process (typically involving Process Analytical Technologies, PAT) can open the possibility to implement sophisticated control strategies. Key components of a control strategy that need to be considered for CT are material tracking and genealogy, knowledge of the residence time distribution (RTD), and in-process controls (spectroscopic and/or soft sensors based on process parameters). Holistically, these control strategy elements enable the implementation of a material diversion strategy to automatically divert out of specification material from the process. In their most advanced form, control strategies may also enable real time release testing (RTRt) of the final tablet drug product and reduce the off-line analytical burden and the number of operators needed to manage the process.   Read the full article at gmp-journal.com  

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