Press Room

News / Jul 18, 2022

Communication of Site Shutdown - Hovione Macau

News release, 18 July 2022

Manufacturing Plant in Macau, China | Hovione

On July 9th, 2022, the Government of the Special Administrative Region of Macau issued the Executive Order No. 115/2022 ordering all industries and commercial businesses located in Macau to suspend operations and shut down from July 11th to July 18th as an extraordinary measure to contain the spread of COVID-19 in the community. In accordance with the executive order, the majority of businesses located in Macau are obliged to shut down from 00:00 on July 11th, 2022 to 00:00 on July 23rd, 2022, including Hovione's manufacturing facility located in the territory. 

 

Since the start of the COVID-19 epidemic, Hovione has been employing procedures and rules to reduce and minimize the impact of forced shutdowns and closures to our manufacturing facilities. Although the temporary suspension of our activities in Macau is beyond the reasonable control of Hovione and mandated by the local government, we will continue to employ all measures to reduce and mitigate the impact of such Interruption on our activities, our customers and partners. 

 

Some of the measures employed at this facility include building up safety stocks of raw materials and finished API, advancing shipment dispatch dates to those clients facing the highest risk of disruption, leveraging bonded warehouses to allow for continued supply of materials, among others. 

 

We commit to immediately notifying you if there are any foreseeable disruptions that may impact your product. Should you have any questions feel free to reach out to your account manager who will be happy to support you. 

 

In the meantime, we will continue to make safe our place of work in order to continue serving our clients and our communities the best we can as we are In it for life

 

 
  
 

About Hovione
Hovione is an international company with over 60 years of experience as a Contract Development and Manufacturing Organization (CDMO) and is currently a fully integrated supplier offering services for drug substance, drug product intermediate and drug product. With four FDA inspected sites in the USA, China, Ireland, and Portugal and development laboratories in Lisbon, Portugal and New Jersey, USA, the company provides branded pharmaceutical customers services for the development and compliant manufacture of innovative drugs including highly potent compounds and customized product solutions across the entire drug life cycle. In the inhalation area, Hovione offers a complete range of and services, from API, formulation development and devices. Hovione was the first Chemical/ Pharmaceutical Company to become a Certified B Corp, is a member of Rx-360, EFCG and participates actively in industry quality improvement initiatives to lead new global industry standards.

 

 
  

Find more about our site, Hovione Macau

 

 

 

 

 

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Continuous Tableting (CT) is defined as continuous manufacturing of oral dose drugs, specifically tablets. As per ICH's Q13 definition1, a continuous manufacturing process in the pharmaceutical industry comprises at least two unit operations integrated from a mechanical and software perspective. There is a wide combination of possible CT process configurations that are dependent on the needs of the intended product formulation and each of the individual unit operations that constitute the process train can be continuous, semi-continuous, or batch processes. The typical manufacturing processes for tablet formulation are direct compression (DC), dry granulation (DG) and wet granulation (WG)2 - details on these manufacturing processes are beyond the scope of this article, so the interested reader is directed to relevant literature. The actual implementation of CT technology in a facility can broadly vary depending on the level of desired integration and automation. Process trains can be designed to be flexible and converted between multiple configurations (e.g. continuous DC, DG and WG), controlled by the end user from one single software and within a single clean room. The other possibility would be for subsections of the CT process to be divided into multiple clean rooms where inprocess materials are transferred between suites via a bin-to-bin approach (e.g. a granulation suite to prepare granules from raw materials followed by continuous DC (CDC) to blend the granules and produce tablets). The level of automation and instrumentation designed into the CT process (typically involving Process Analytical Technologies, PAT) can open the possibility to implement sophisticated control strategies. Key components of a control strategy that need to be considered for CT are material tracking and genealogy, knowledge of the residence time distribution (RTD), and in-process controls (spectroscopic and/or soft sensors based on process parameters). Holistically, these control strategy elements enable the implementation of a material diversion strategy to automatically divert out of specification material from the process. In their most advanced form, control strategies may also enable real time release testing (RTRt) of the final tablet drug product and reduce the off-line analytical burden and the number of operators needed to manage the process.   Read the full article at gmp-journal.com  

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